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Other microscopic findings likely to be attributable to treatment included hypocellularity of the bone marrow, lesions in the gastrointestinal tract (gastritis, oedema, and ulceration) and heart (haemorrhage), and thymic atrophy at the high dose, and an increased incidence of nephritis, centrilobular degeneration in the liver, lymphadenitis, and splenic hyperplasia at both 1000 and 3000 ppm